Streptococci account for 10-20% of orthopedic implant-associated infections, including prosthetic joints, spine, native joints and breast implants. Moreover, streptococci are the most common organisms causing intravascular infections, both of native valves (infective endocarditis), as well as device-associated such as cardiac pacemaker/ICD, vascular prosthesis or prosthetic valve endocarditis.
They mostly originate from the oral cavity and have high clinical relevance, since they cause life-threatening intravascular infections.
The goal of this project is to evaluate the activity of an “old” antibiotic, fosfomycin, against streptococci, alone and in combination with rifampin, daptomycin and gentamicin in vitro and in the experimental model. Streptococcus oralis, Strepococcus agalactiae and Streptococcus mitis will be investigated first, followed by Abiotrophia adiacens and Granulicatella elegans.
This project may open new treatment possibilities for intra- end extravascular implant-associated infections.