Biofilm microorganisms are up to 1,000 times more resistant to antibiotics than their planktonic (free-living) counterparts. The increasing development of antibiotic resistance problems lead to the investigation of new ways to fight biofilm infections, such as the use of bacteriophages.
The antibacterial property of bacteriophages were discovered in the former Soviet Republic of Georgia and research on bacteriophages for treating bacterial infection was extensively performed between 1920 and 1940s.
The goal of this project is to investigate the activity of specific bacteriophages against planktonic and biofilm bacteria, including multiresistant pathogens in vitro (conventional microbiology, microcalorimetry, imaging) and in vivo (animal model of biofilms). The local and systemic activity of bacteriophages will be investigated alone and in combination with antimicrobials. Target microorganisms are staphylococci, enterococci and gram-negative bacilli.
This innovative project may lead to new treatment concepts for difficult-to-treat infections, for which there are no antibiotics available at the moment.